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Partanen T, Rissanen A

doi: 10.3389/ftox.2021.730752 Received 25 June 2021 Accepted 13 October 2021 Published 27 October 2021 Volume 3 - 2021 Edited by Rosaria Meccariello, University of Naples Parthenope, Italy Reviewed by Jennifer Anne Thompson, University of Calgary, Canada Anderson J Martino-Andrade, Universidade Federal do Paran, Brazil Updates Copyright 2021 Schwartz, Christiansen, Hass, Ramhj, Axelstad, Lbl and Svingen

We found that the combination PS and suPAR improved the c -statistics and this phenomenon raised another possibility of another mechanism of podocyte injury, e.g., suPAR is binding to and activating v 3 integrins on podocytes, a process that leads to activation of small GTPase Rac-1 which in turns drives podocyte foot process motility and foot process effacement 47

This transient effect, consistently observed in both in vitro and in vivo studies, underscores the necessity of repeated dosing to maintain systemic exposure and achieve meaningful metabolic benefits

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